Southampton and Watford will be aiming for three points at St Mary’s on Saturday after disappointing results last weekend.
The hosts were crushed 6-1 by Manchester City and this week have trained at their own stadium as manager Mark Hughes tries desperately to turn their season around.
The travelling Hornets, meanwhile, come into the game on the back of a poor 1-0 loss at the hands of relegation-threatened Newcastle United.
But who will come out on top in the 3pm kick-off?
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What are the managers saying?
Mark Hughes (Southampton): “I’d be very disappointed if we didn’t go in with the attitude that this is a game that we’ll target to win. Our intention is to get maximum points.
“We’re in a situation that people think we’re under a little bit of pressure, so we’ve got to use that as a motivation going into this game.
“Watford are a good team, have had a good start, but we feel we’re more than capable of beating them.
“This is a real opportunity now to start our season in earnest.”
Javi Gracia (Watford): “I’m proud to be Watford manager.
“I don’t know how long I’ll be here, but I’m very proud to be at this club, to have the supporters we have, and to enjoy every day with the players. I’m very proud of all of them.”
Wesley Hoedt and Mario Lemina have both recovered from injury to start for Saints.
Hornets captain Troy Deeney is on the bench as he returns from a hamstring issue, but Sebastian Prodl (hamstring) and Daryl Janmaat (knee) remain sidelined.
Elsewhere, Etienne Capoue is suspended for the match at St Mary’s and while Tom Cleverley is finally back training he is not fit enough to play.
Southampton: McCarthy, Cedric, Hoedt, Yoshida, Bertrand, Armstrong, Hojbjerg, Lemina, Redmond, Ings, Gabbiadini.
Subs: Vestergaard, Stephens, Austin, Elyounoussi, Ward-Prowse, Gunn, Obafemi.
Watford: Foster, Femenia, Cathcart, Mariappa, Holebas, Doucoure, Chalobah, Deulofeu, Hughes, Pereyra, Success.
Subs: Gomes, Deeney, Masina, Gray, Wilmot, Kabasele, Okaka.